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The exact mechanism of membrane disruption and cell death by the chimeric peptides and how these effects are related to BamA binding is. , Azerad R.
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One way of reducing the threat of AMR organisms is to develop antibiotics against novel targets.
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The natural peptide thanatin kills Gram-negative bacteria by targeting proteins of the lipopolysaccharide transport (Lpt) machinery.
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There is an urgent need for new antibiotics against Gram-negative pathogens that are resistant to carbapenem and third-generation cephalosporins.
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